Avmacol® Extra Strength

Sulforaphane Support with Beta-Glucan

• Detoxification Support*
  Avmacol® Extra Strength builds on the regular formula by adding beta-glucan to support your body’s natural detoxification process and overall cellular health, working better than sulforaphane alone.*
• Sulforaphane Production System®
  This formula features our Sulforaphane Production System®—a combination of broccoli seed and sprout extract (glucoraphanin) and active myrosinase enzyme (Myrosimax®)—to help your body produce sulforaphane, a compound that supports internal defense systems.* 
  
• Works Synergistically
  Avmacol® Extra Strength includes beta-glucan and maitake mushroom, known for their immune properties, to work synergistically with our sulforaphane-producing blend.*
• Backed by Research
  Avmacol® has been selected for use in more sulforaphane human clinical trials than any other supplement.▲ Our formula can be trusted by researchers and backed by science.
  
• Made with Quality You Can Trust
  Avmacol® Extra Strength is manufactured under strict quality standards and tested for stability.

What is Avmacol® Extra Strength

Avmacol® Extra Strength is a patented, sulforaphane-producing supplement that works in combination with Maitake mushroom extract (containing beta-glucans) to support your body's natural detoxification process better than sulforaphane alone.* Avmacol® Extra Strength provides glucoraphanin, also known as sulforaphane glucosinolate, and active myrosinase enzyme, which are the essential ingredients needed for sulforaphane production. Without active myrosinase enzyme, one may not be able to reap sulforaphane’s many health-promoting benefits.

How Maitake Mushroom Extract Works in Combination with Sulforaphane

The Maitake mushroom extract (containing beta-glucans) works in combination with sulforaphane to support your body’s natural detoxification process better than sulforaphane alone.* In addition, the Maitake mushroom extract found in Avmacol® Extra Strength provides the added bonus of immune support by promoting neutrophil function and natural killer cell activity.

The Science Behind Avmacol® Extra Strength

The combination of sulforaphane and Maitake extract supports the movement (or translocation) from the cytoplasm to the nucleus of NRF2 and increases the levels of certain Phase 2 enzymes. Below are images of a technique called immunofluorescence which illustrate how much protein is being produced in the cell and the location of that protein.

Translocation of NRF2 into the Nucleus Following Exposure to Sulforaphane and Maitake Mushroom Extract

control

sulforaphane + maitake

In control cells (left panel), the green staining indicates that NRF2 remains largely in the cytoplasm (arrows) without much protein located in the nucleus, which is counter-stained in blue. When cells are exposed to sulforaphane and Maitake (right panel), NRF2 moves to the nucleus (arrows) where it can bind to DNA to turn on expression of certain Phase 2 enzymes.

Sulforaphane and Maitake Extract Boosts Select Phase 2 Enzyme Production Including NQO1 and HO-1

NQO1 Protein Expression in THLE2 Liver Cells

control

sulforaphane + maitake

In control cells (left panel) NQO1 protein expression is indicated by the green staining. When cells are exposed to sulforaphane and Maitake (right panel), the level of NQO1 staining, representing the amount of protein, is increased.

HO-1 Protein Expression in THLE2 Liver Cells

control

sulforaphane + maitake

In control cells (left panel) HO-1 protein expression is indicated by the green staining. When cells are exposed to sulforaphane and Maitake (right panel), the level of HO-1 staining, representing the amount of protein, is increased.

Who Would Benefit from Avmacol® Extra Strength?

We are capable of incredible things; and when our bodies get the support they need, the results can be amazing. Avmacol^® unleashes the power of broccoli to help your body fight off toxin-related stress at the cellular level.

 

 

▲The Avmacol® brand has been selected for use in more sulforaphane human clinical trials than any other sulforaphane-producing supplement in the marketplace.